منابع مشابه
What does the mediodorsal thalamus do?
Dense amnesia can result from damage to the medial diencephalon in humans and in animals. In humans this damage is diffuse and can include the mediodorsal nuclei of the thalamus. In animal models, lesion studies have confirmed the mediodorsal thalamus (MD) has a role in memory and other cognitive tasks, although the extent of deficits is mixed. Anatomical tracing studies confirm at least three ...
متن کاملInhibition of Mediodorsal Thalamus Disrupts Thalamofrontal Connectivity and Cognition
Cognitive deficits are central to schizophrenia, but the underlying mechanisms still remain unclear. Imaging studies performed in patients point to decreased activity in the mediodorsal thalamus (MD) and reduced functional connectivity between the MD and prefrontal cortex (PFC) as candidate mechanisms. However, a causal link is still missing. We used a pharmacogenetic approach in mice to dimini...
متن کاملMediodorsal thalamus and cognition in non-human primates
Several recent studies in non-human primates have provided new insights into the role of the medial thalamus in different aspects of cognitive function. The mediodorsal nucleus of the thalamus (MD), by virtue of its connectivity with the frontal cortex, has been implicated in an array of cognitive functions. Rather than serving as an engine or relay for the prefrontal cortex, this area seems to...
متن کاملWhat Does PLIER Really Do?
MOTIVATION Our goal was to understand why the PLIER algorithm performs so well given its derivation is based on a biologically implausible assumption. RESULTS In spite of a non-intuitive assumption regarding the PM and MM errors made as part of the derivation for PLIER, the resulting probe level error function does capture the key characteristics of the ideal error function, assuming MM probe...
متن کاملWhat does a compiler do ?
Machine Interpreter P.abs Abstract Machine Code Integrated Programming Environment with Structure Editor, Compiler, and Debugger.
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ژورنال
عنوان ژورنال: Frontiers in Systems Neuroscience
سال: 2013
ISSN: 1662-5137
DOI: 10.3389/fnsys.2013.00037